Mercredi 27 mars 2013 à 14h15
Salle 234, Ecole de Physique

Nonequilibrium physics in biochemical networks: the energy cost of adaptiation

Yuhai Tu, IBM T. J. Watson Research Center

Adaptation is one of the most important phenomena in living systems. By studying simple biochemical networks underlying most biological sensory adaptation systems, we find that adaptation processes are necessarily dissipative and continuous energy consumption is required to mantain the adapted steady state [1]. Ous study reveals a universal relation among energy dissipation rate, adaptation speed, and the maximum adaptation accuracy. This energy-speed-accuracy (ESA) relation is verified in the Escherichia colo chemosensory system by direct measurements and detailed modeling. Our work provides a possible general principle governing cost-performance tradeoffs for regulatory functions and invormation processes in living cells. [1]"the energy-speed-accuracy trade-off in sensory adaptation", G.Lan, P.Sartori, S.Neumann, V.Sourjik, Yuhai Tu, Nature Physics, March 2012..